Recombinant Rabbit Monoclonal Antibody to Paxillin (Clone: RM256)(Discontinued)
Figure 1: Western Blot of HeLa cell lysate, using anti-Paxillin rabbit monoclonal Antibody Clone: RM256 at a 1:1000 dilution.
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Purification : | Protein A affinity purified from an animal origin-free culture supernatant |
| Content : | Antibody in 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Storage condition : | Store at -20°C. Avoid repeated freeze and thaw cycles. |
Clone RM256 reacts to human Paxillin. This antibody may also react to mouse or rat Paxillin, as predicted by immunogen homology. Immunocytochemistry (ICC): 1:1000-1:2000 dilution; Western Blot (WB): 1:1000-1:2000 dilution.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Cell junction, Cytoplasm |
| Post transnational modification: | Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389). |
| BioGrid: | 111787. 98 interactions. |
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