Recombinant Rabbit Monoclonal Antibody to HER2 (Clone: RM228)(Discontinued)
Figure 1: Immunohistochemical staining of FFPE human breast cancer tissue sections, using Anti-HER2 (c-erbB-2) Rabbit Monoclonal antibody Clone: RM228.
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Purification : | Protein A affinity purified from an animal origin-free culture supernatant |
| Content : | Antibody in 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Storage condition : | Store at -20°C. Avoid repeated freeze and thaw cycles. |
Clone RM228 reacts to Human c-erbB-2/HER-2. This antibody may also react to mouse or rat c-erbB-2/HER-2, as predicted by immunogen homology. Immunohistochemistry (IHC): 1:100 - 1:400 dilution; Western Blot (WB): 1:1000 dilution.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus |
| Post transnational modification: | Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172). |
| Tissue Specificity: | Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. |
| BioGrid: | 108376. 234 interactions. |
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