Recombinant Rabbit Monoclonal Antibody to CD146, MCAM, MUC18 (Clone: RM249)(Discontinued)

Product code: 10-9610

Clone name : RM249
Clonality : Monoclonal
Application : WB, IHC
Reactivity : Human, Mouse, Rat

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Purification : Protein A affinity purified from an animal origin-free culture supernatant
Content : Antibody in 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Storage condition : Store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : MCAM
Gene ID : 4162
Uniprot ID : P43121
Alternative Name : MCAM, MUC18
Immunogen Information : A synthetic peptide corresponding to the residues near C-terminus of human CD146

Clone RM249 reacts to human CD146 (Cell surface glycoprotein MUC18). This antibody may also react to mouse or rat CD146, as predicted by immunogen homology. Immunohistochemistry (IHC): 1:200-1:500 dilution; Western Blot (WB): 1:1000-1:2000 dilution.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
Tissue Specificity: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.
BioGrid: 110332. 15 interactions.
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