Recombinant Rabbit Monoclonal Antibody to Akt1 (Clone: RM252)(Discontinued)

Product code: 10-9614

Clone name : RM252
Clonality : Monoclonal
Application : WB, IHC
Reactivity : Human, Mouse, Rat

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Purification : Protein A affinity purified from an animal origin-free culture supernatant
Content : Antibody in 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Storage condition : Store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : AKT1
Gene ID : 207
Uniprot ID : P31749
Alternative Name : AKT1, PKB, RAC
Immunogen Information : A synthetic peptide corresponding to the C-terminus of human Akt1

Clone RM252 reacts to human Akt1. This antibody may also react to bovine, mouse or rat Akt1, as predicted by immunogen homology. Immunohistochemistry (IHC): 1:500-1:1000 dilution; Western Blot (WB): 1:1000-1:2000 dilution.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus, Cell membrane
Post transnational modification: Acetylated on Lys-14 and Lys-20 by the histone acetyltransferases EP300 and KAT2B. Acetylation results in reduced phosphorylation and inhibition of activity. Deacetylated at Lys-14 and Lys-20 by SIRT1. SIRT1-mediated deacetylation relieves the inhibition.
Tissue Specificity: Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
BioGrid: 106710. 302 interactions.
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