Rabbit Monoclonal Antibody to human CTLA-4 (Clone:ABM2D9.1G3)(Discontinued)
Figure 1: Cell surface staining of PHA stimulated PBMC. Green represents isotype control, red represents anti-hCTLA4 (10-7633). 0.5 ug antibody was used. Goat anti-rabbit PE was used as secondary antibody.
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Shipping Info:
Order now and get it on Wednesday December 25, 2024
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
Flowcytometric Analysis: 0.5-1 µg/10^6 Cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. |
| Tissue Specificity: | Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. |
| BioGrid: | 107875. 109 interactions. |
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