Polyclonal Antibody to Tubulin beta-III
Figure 1: Western blot analysis of extract from Mouse brain tissue, Hela, JK and P19 cells using Tubulin beta-III Antibody 35-1787
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the a-chain. TUBB3 plays a critical role in proper axon guidance and mantainance.
Predicted MW: 55kd, Western blotting: 1:500~1:1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm |
| Post transnational modification: | Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules. |
| Tissue Specificity: | Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. |
| BioGrid: | 115654. 280 interactions. |
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