Polyclonal Antibody to Smad1 (Ab-465)

Product code: 35-1642

Clonality : Polyclonal
Application : WB, IF
Reactivity : Human, Mouse, Rat

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : SMAD1
Gene ID : 4086
Uniprot ID : Q15797
Alternative Name : Mad-related protein 1, SMAD 1, hSMAD1, Transforming growth factor-beta-signaling protein 1
Immunogen Information : Peptide sequence around aa. 461~465 (I-S-S-V-S) derived from Human Smad1.
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).

Predicted MW: 55kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Post transnational modification: Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes. Dephosphorylation, probably by PPM1A, induces its export from the nucleus to the cytoplasm (By similarity).
Tissue Specificity: Ubiquitous. Highest expression seen in the heart and skeletal muscle.
BioGrid: 110261. 125 interactions.
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