Polyclonal Antibody to SHP-2 (Ab-580)

Product code: 35-1641

Clonality : Polyclonal
Application : IHC, WB, IF
Reactivity : Rat, Mouse, Human

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : PTPN11
Gene ID : 5781
Uniprot ID : Q06124
Alternative Name : Protein-tyrosine phosphatase 2C
Immunogen Information : Peptide sequence around aa.578~582 (R-V-Y-E-N) derived from Human SHP-2.

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

Predicted MW: 72kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Post transnational modification: Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.
Tissue Specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle.
BioGrid: 111745. 178 interactions.
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