Polyclonal Antibody to SEK1/MKK4 (Ab-261)

Product code: 35-1479

Clonality : Polyclonal
Application : IHC, IF
Reactivity : Human, Mouse, Rat

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  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : MAP2K4
Gene ID : 6416
Uniprot ID : P45985
Alternative Name : JNKK, JNKK1, MAP2K4, MAPK/ERK kinase 4, MAPKK 4
Immunogen Information : Peptide sequence around aa.259~263 (A-K-T-R-D) derived from Human SEK1/MKK4.
Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).

Predicted MW: 44kd, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Post transnational modification: Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks).
Tissue Specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
BioGrid: 112315. 43 interactions.
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