Polyclonal Antibody to PKC Zeta (Ab-410)

Product code: 35-1636

Clonality : Polyclonal
Application : WB, IHC
Reactivity : Human, Mouse, Rat

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  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : PRKCZ
Gene ID : 5590
Uniprot ID : Q05513
Alternative Name : PKC2, PKC-ZETA, PRKCZ
Immunogen Information : Peptide sequence around aa. 408~412 ( T-S-T-F-C) derived from PKCz
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.

Predicted MW: 78kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm
Post transnational modification: CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase.
Tissue Specificity: Expressed in brain, and to a lesser extent in lung, kidney and testis.
BioGrid: 111576. 90 interactions.
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