Polyclonal Antibody to Pin1(Discontinued)
Figure 1: HeLa cells stained with 34-1104 antibody to Pin-1 (1:1,000 dilution, green) and monoclonal to fibrillarin, 34-1031 (red). Pin-1 stains the nuclear matrix and, much more faintly, the cytoplasm. The fibrillarin antibody marks nucleoli.
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Shipping Info:
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| Format : | Conc. IgY prep. |
| Amount : | 100 µl |
| Isotype : | Chicken, IgY |
| Content : | Antibody is supplied as an aliquot of concentrated IgY prep. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
Western blot: 1:20,000. ICC/IF and IHC: 1:2,000.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Nucleus speckle, Cytoplasm |
| Post transnational modification: | Phosphorylation at Ser-71 by DAPK1 results in inhibition of its catalytic activity, nuclear localization, and its ability to induce centrosome amplification, chromosome instability and cell transformation. |
| Tissue Specificity: | The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. |
| BioGrid: | 111317. 244 interactions. |
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