Polyclonal Antibody to p70 S6 Kinase (Ab-421) (Discontinued)

Product code: 35-1579

Clonality : Polyclonal
Application : IHC, WB
Reactivity : Rat, Mouse, Human

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Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : RPS6KB1
Gene ID : 6198
Uniprot ID : P23443
Alternative Name : KS6B1, P70-S6K, RPS6KB1, S6K
Immunogen Information : Peptide sequence around aa.419~423 (P-R-T-P-V) derived from Human p70 S6 Kinase.

Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.

Predicted MW: 70 85 kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm
Post transnational modification: Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an agonist-dependent autophosphorylation mechanism (By similarity). Activated by phosphorylation at Thr-252 by PDPK1. Dephosphorylation by PPP1CC at Thr-412 in mitochondrion.
Tissue Specificity: Widely expressed.
BioGrid: 112112. 71 interactions.
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