Polyclonal Antibody to Nucleophosmin

Product code: 11-4033

Clonality : Polyclonal
Application : IHC, WB
Reactivity : Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $100.00 

  • $270.00 

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Shipping Info:

Order now and get it on Thursday December 26, 2024

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Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : NPM1
Gene ID : 4869
Uniprot ID : P06748
Alternative Name : Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM
Immunogen Information : A partial length recombinant Nucleophosmin protein (amino acids 18-236) was used as the immunogen for this antibody.

Nucleophosmin (NPM1) is a multifunctional, ubiquitously expressed nucleolar phoshoprotein which shuttles continuously between the nucleus and cytoplasm and plays an important role in cell proliferation and apoptosis. This protein exerts its functions through the interaction with a multiplicity of biological partners, specifically recognizes DNA G-quadruplexes through its C-terminal region. It is mainly localized in the nucleolus and has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. Mutations at exon 12 of NPM1 gene is a hallmark of cytogenetically normal acute myeloid leukemia.

Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml

 

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus, Nucleus, Cytoplasm
Post transnational modification: May be ubiquitinated. Ubiquitination leads to proteasomal degradation.
Tissue Specificity: Expressed in B-cells that have been induced to switch to various Ig isotypes.
BioGrid: 201823. 45 interactions.
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