Polyclonal Antibody to NALP3

Product code: 11-3024

Clonality : Polyclonal
Application : WB
Reactivity : Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $100.00 

  • $270.00 

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Shipping Info:

Order now and get it on Thursday October 31, 2024

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Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : NLRP3
Gene ID : 114548
Uniprot ID : Q96P20
Alternative Name : NLRP3, C1orf7, CIAS1, NALP3, PYPAF1
Immunogen Information : A partial recombinant NALP3 protein (amino acids 1-200) was used as the immunogen for this antibody.

NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein-protein interaction, an intermediate nucleotide binding self-oligomerization NACHT domain and a C-terminal domain containing leucine-rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappa signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.

Western blot analysis: 2-4 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Inflammasome, Endoplasmic reticulum, Secreted, Nucleus
Post transnational modification: The disulfide bond in the pyrin domain might play a role in reactive oxygen species-mediated activation.
BioGrid: 125319. 49 interactions.
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