Polyclonal Antibody to MEK1/MEK2 (Ab-217/221)
Figure 1: Western blot analysis of extracts from 293 cells using MEK1/MEK2(Ab-217/221) Antibody 35-1541 and the same antibody preincubated with blocking peptide.
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | MAP2K1 |
| Gene ID : | 5604 |
| Uniprot ID : | Q02750 |
| Alternative Name : | ERK activator kinase 1/ERK activator kinase2, MAP kinase kinase 1/MAP kinase kinase 2, MAP2K1/MAP2K1, MAPK/ERK kinase 1/MAPK/ERK kinase 2, MAPKK 1/MAPKK 1 |
| Immunogen Information : | Peptide sequence around aa.215~219/219~223 (I-D-S-M-A) derived from Human MEK1/MEK2. |
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
Predicted MW: 45kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Cytoplasm, Cytoplasm, Nucleus, Membrane |
| Post transnational modification: | Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| Tissue Specificity: | Widely expressed, with extremely low levels in brain. |
| BioGrid: | 111590. 121 interactions. |
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