Polyclonal Antibody to MARCKS (phospho-Ser170)

Product code: 35-1318

Clonality : Polyclonal
Application : WB, IHC
Reactivity : Human

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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For estimated delivery dates, please contact us at [email protected]


Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : MARCKS
Gene ID : 4082
Uniprot ID : P29966
Alternative Name : MACS, 80K-L, PKCSL, PRKCSL
Immunogen Information : Peptide sequence around phosphorylation site of Serine 170 (G-F-S(p)-F-K) derived from Human MARCKS.
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. Ramsden, J.J. (2000) Int. J. Biochem. Cell Biol. 32, 475-479. Graff, J. M. et al. (1989) J. Biol. Chem. 264, 21818-21823. Hartwig, J. H. et al. (1992) Nature 356, 618-622. Thelen, M. et al. (1991) Nature 351, 320-322.

Predicted MW: 80kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Membrane
Post transnational modification: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.
BioGrid: 110257. 40 interactions.
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