Polyclonal Antibody to MAP2
Figure 1: Western blot analysis of extract from C6 cells using MAP2 Antibody 35-1804
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr. Proteome Res. 4:306-315(2005) Olsen J.V., Blagoev B., Gnad F., Macek B. Mann M.Cell 127:635-648(2006) Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. Science 316:1160-1166(2007)
Predicted MW: 55-75(2c/2d), 280(2a/2b)kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Cell projection |
| Post transnational modification: | Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity). |
| BioGrid: | 110305. 48 interactions. |
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