Polyclonal Antibody to Lamin A/C

Product code: 11-8117

Clonality : Polyclonal
Application : WB
Reactivity : Rat, Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $100.00 

  • $270.00 

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Shipping Info:

Order now and get it on Wednesday November 06, 2024

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Format : Purified
Amount : 100 µg
Isotype : Rabbit IgG
Purification : Protein A Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : LMNA
Gene ID : 4000
Uniprot ID : P02545
Alternative Name : 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMN1
Immunogen Information : A partial length recombinant Lamin A/C protein (amino acids 235-450) was used as the immunogen for this antibody.

Recommended dilutions: WB: 1-2 µg/ml. However, this need to be optimized based on the research applications.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus speckle
Post transnational modification: Farnesylation of prelamin-A/C facilitates nuclear envelope targeting.
Tissue Specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
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