Polyclonal Antibody to Lamin A/C (Discontinued)
Figure 1: HeLa cells staing with 34-1059 (red) counterstained with monoclonal antibody to HSP27, 34-1050 (green) and DNA (blue). The 34-1059 antibody reveals strong nuclear lamina staining, while the 34-1050 antibody reveals strong cytoplasmic staining. Since both DNA (blue) and Lamin A/C (red) are associated with the nuclear compartment, this region appears crimson in this image.
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Shipping Info:
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| Format : | Sera |
| Amount : | 100 µl |
| Isotype : | Rabbit, IgG |
| Content : | Antibody is supplied as an aliquot of serum |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
Western blot: 1:5,000 IF/ICC and IHC: 1:5,000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus speckle |
| Post transnational modification: | Farnesylation of prelamin-A/C facilitates nuclear envelope targeting. |
| Tissue Specificity: | In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. |
| BioGrid: | 110186. 661 interactions. |
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