Polyclonal Antibody to HSF1 (phospho-Ser303)
Figure 1: Western blot analysis of extracts from MCF7 cells using HSF1(phospho-Ser303) Antibody 35-1242 (Lane 2) and the same antibody preincubated with blocking peptide(Lane1).
Roll over image to zoom in
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
Parvaneh Rafiee, et,al. (2006) Am J Physiol Cell Physiol ; 291: C931 - C945
Fumika Shinozaki, et,al. (2006) J. Biol. Chem ; 281: 16361 - 16369.
Eiichi Takaki, et,al. (2006) J. Biol. Chem ; 281: 4931 - 4937.
Jan-Jong Hung, et,al. (1998) J. Biol. Chem ; 273: 31924.
Predicted MW: 82kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm, Nucleus, Cytoplasm, Cytoplasm, Cytoplasm, Chromosome |
| Post transnational modification: | Ubiquitinated by SCF(BTRC) and degraded following stimulus-dependent phosphorylation at Ser-216 by PLK1 in mitosis (PubMed:18794143). Polyubiquitinated (PubMed:24581496). Undergoes proteasomal degradation upon heat shock and during the attenuation and recovery phase period of the heat shock response (PubMed:24581496). |
| BioGrid: | 109530. 116 interactions. |
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
