Polyclonal Antibody to GRASP

Figure 1: Western blot analysis of extracts from rat brain and mouse brain tissue using GRASP Antibody 35-1692

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Product code: 35-1692

Clonality :	Polyclonal
Application :	WB
Reactivity :	Human, Mouse, Rat

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Download TDS MSDS

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Format :	Purified
Amount :	100 µl
Isotype :	Rabbit IgG
Content :	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	Gripap1
Gene ID :	116493
Uniprot ID :	Q9JHZ4
Alternative Name :	Gripap, Grasp, GRIP1-associated protein
Immunogen Information :	Peptide sequence around aa. 814-818(Q-E-I-V-R ) derived from Rat GRASP.

GRASP (GRP1-associated scaffold protein, tamalin) is a 395 amino acid protein encoded by the human gene GRASP . GRASP is a scaffold protein that com-prises multiple protein-interacting domains, including a 95 kDa postsynaptic density protein (PSD-95)/discs-large/ZO-1 (PDZ) domain, a leucine-zipper region and a carboxyl-terminal PDZ-binding motif. GRASP is involved with intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. GRASP forms a heteromer composed of GRASP , PSCD2 and at least one mGluR-1. It also interacts with PSCD3, mGluR-2, mGluR-3 and mGluR-5. GRASP is highly expressed in brain and has lower levels of expression in lung, heart, embryo, kidney and ovary.

Predicted MW: 95kd, Western blotting: 1:500~1:1000

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Early endosome membrane, Recycling endosome membrane, Cell projection, Cell projection, Cell junction
Post transnational modification:	Proteolytically cleaved by caspase-3 (PubMed:10896157). A minor C-terminal proteolytic fragment of 30 kDa is produced (PubMed:10896157). Proteolytic cleavage is required for JNK signaling activation (PubMed:17761173).
Tissue Specificity:	Expressed in the central nervous system; especially in neurons.
BioGrid:	250467. 1 interactions.