Polyclonal Antibody to GRASP
Figure 1: Western blot analysis of extracts from rat brain and mouse brain tissue using GRASP Antibody 35-1692
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
GRASP (GRP1-associated scaffold protein, tamalin) is a 395 amino acid protein
encoded by the human gene GRASP . GRASP is a scaffold protein that com-prises multiple protein-interacting domains, including a 95 kDa postsynaptic density protein (PSD-95)/discs-large/ZO-1 (PDZ) domain, a leucine-zipper
region and a carboxyl-terminal PDZ-binding motif. GRASP is involved with intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. GRASP forms a heteromer composed of GRASP , PSCD2 and at least one mGluR-1. It also interacts with PSCD3, mGluR-2, mGluR-3 and mGluR-5. GRASP is highly expressed in brain and has lower levels of expression in lung, heart, embryo, kidney and ovary.
Predicted MW: 95kd, Western blotting: 1:500~1:1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Early endosome membrane, Recycling endosome membrane, Cell projection, Cell projection, Cell junction |
| Post transnational modification: | Proteolytically cleaved by caspase-3 (PubMed:10896157). A minor C-terminal proteolytic fragment of 30 kDa is produced (PubMed:10896157). Proteolytic cleavage is required for JNK signaling activation (PubMed:17761173). |
| Tissue Specificity: | Expressed in the central nervous system; especially in neurons. |
| BioGrid: | 250467. 1 interactions. |
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