Polyclonal Antibody to CRY1

Product code: 35-1668

Clonality : Polyclonal
Application : WB
Reactivity : Mouse

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  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : CRY1
Gene ID : 1407
Uniprot ID : Q16526
Alternative Name : PHLL1
Immunogen Information : Peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Human CRY1.
Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45. Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8. Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.

Predicted MW: 60kd, Western blotting: 1:500~1:1000

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Post transnational modification: Undergoes autophagy-mediated degradation in the liver in a time-dependent manner. Autophagic degradation of CRY1 (an inhibitor of gluconeogenesis) occurs during periods of reduced feeding allowing induction of gluconeogenesis and maintenance of blood glucose levels.
BioGrid: 107797. 148 interactions.
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