Polyclonal Antibody to CRHR2
Fig-1: Western blot analysis of CRHR2. Anti- CRHR2 antibody (11-8023) was used at 0.5 µg/ml on T98G lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
CRHR2 (CRF2R, CRH2R) (corticotropin releasing hormone receptor 2) belongs to the G-protein coupled receptor 2 family. This receptor has high affinity for corticotropin releasing hormone (CRH) and may also bind to CRH-related peptides, such as, urocortin. The human CRHR2 gene contains 12 exons. Three major functional isoforms have been reported: alpha, beta and gamma encoded by transcripts with alternative first exons which differ from each other by signal sequence and extra-cellular domain. CRH is synthesized in the hypothalamus and plays an important role in coordinating the endocrine, autonomic and behavioral responses to stress and immune challenge. CRHR2 has high expression in brain, caudate nucleus, cerebrum, colon, endometrium, etc.
Western blot analysis: 0.5-2.0 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Post transnational modification: | A N-glycosylation site within the signal peptide impedes its proper cleavage and function. |
| BioGrid: | 107785. 2 interactions. |
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