Polyclonal Antibody to Caveolin-2
Figure 1: Western blot analysis of extracts from Hela and HUVEC cells using Caveolin-2 Antibody 35-1855 .
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | 1.0 mg/ml,100 µl |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
Predicted MW: 18 22kd, Western blotting: 1:500~1:1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Golgi apparatus membrane, Cell membrane, Membrane, Membrane raft, Golgi apparatus |
| Post transnational modification: | Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress. |
| Tissue Specificity: | Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain. |
| BioGrid: | 107305. 199 interactions. |
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