Polyclonal Antibody to BRCA1 (Phospho-Ser988)

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation Lin SY, et al. (2004) Proc Natl Acad Sci U S A, 101(17): 6484-6489 Zhang J, et al. (2004) Mol Cell Biol; 24(2): 708-718 Beger C, et al. (2001) Proc Natl Acad Sci U S A; 98(1): 130-135 Gardner K, et al. (2001) Breast Cancer Res; 3(1): 11-13 Zheng L, et al. (2001) Proc Natl Acad Sci U S A; 98(17): 9587-9592

Predicted MW: 220kd, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cytoplasm
Post transnational modification:	Phosphorylation at Ser-308 by AURKA is required for normal cell cycle progression from G2 to mitosis. Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-988 by CHEK2 regulates mitotic spindle assembly.
Tissue Specificity:	Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines.
BioGrid:	107140. 1008 interactions.

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