Polyclonal Antibody to Brachyury
Fig-1: Western blot analysis of Brachyury. Anti- Brachyury antibody (11-10026) was used at 4 µg/ml on Testis lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Brachyury is a transcription factor encoded by T, a member of the T-box gene family, and required for posterior mesoderm formation and differentiation as well as for notochord development. It is expressed in all nascent mesoderm, in the embryo. Along with embryonic differentiation, it is downregulated, restricted into the notochord and the tail bud, and then lost, when notochordal cells are replaced by bone in the vertebral bodies and by the nucleus pulposus in the intervertebral discs. In the adult, brachyury expression has been found in chordoma, a malignant tumor which recapitulates notochord and derives from small collections of notochordal cells which may persist into the adult life.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus |
| Tissue Specificity: | Detected in testis, but not in other, normal tissues. Detected in lung tumors (at protein level). |
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