Polyclonal Antibody to ASPSCR1
Figure 1: Western blot analysis of extracts from HL60 cells using ASPSCR1 Antibody 35-1682 .
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Format : | Purified |
Amount : | 100 µl |
Isotype : | Rabbit IgG |
Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.
Predicted MW: 70-75kd, Western blotting: 1:500~1:1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Subcellular location: | Endomembrane system, Endoplasmic reticulum-Golgi intermediate compartment membrane, Cytoplasm, Nucleus |
Tissue Specificity: | Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. |
BioGrid: | 122516. 53 interactions. |
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