Polyclonal Antibody to ASK1 (Ab-83)

Product code: 35-1474

Clonality : Polyclonal
Application : WB, IHC, IF
Reactivity : Human

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $374.00 

  • $437.00 

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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : MAP3K5
Gene ID : 4217
Uniprot ID : Q99683
Alternative Name : ASK-1, M3K5, MAP3K5, MAPK/ERK kinase kinase 5, MAPKKK5
Immunogen Information : Peptide sequence around aa.81~85 (G-S-S-V-G) derived from Human ASK1.
Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.

Predicted MW: 155kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Endoplasmic reticulum
Post transnational modification: Ubiquitinated. Tumor necrosis factor (TNF) induces TNFR2-dependent ubiquitination leading to proteasomal degradation.
Tissue Specificity: Abundantly expressed in heart and pancreas.
BioGrid: 110381. 99 interactions.
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