Polyclonal Antibody to Anti-MCC Antibody(Discontinued)
Figure 1: Anti-MCC antibody(39-2151). All Western blotting: All Lanes: Anti-MCC(39-2151) at 0.5ug/ml. Lane 1: Rat Brain Tissue Lysate at 40ug, Lane 2: 293T Whole Cell Lysate at 40ug, Lane 3: NIH Whole Cell Lysate at 40ug, Lane 4: A549 Whole Cell Lysate at 40ug, Lane 5: HEPG2 Whole Cell Lysate at 40ug. Predicted band size: 93 kDa.Observed band size: 93 kDa.
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| Amount : | 100 μg/vial |
| Isotype : | Rabbit IgG |
| Purification : | Immunogen affinity purified. |
| Content : | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Storage condition : | At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing. |
MUTATED IN COLORECTAL CANCERS(MCC) is a tumor suppressor gene. It is mapped to 5q22.2. This gene suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. MCC also Inhibits DNA binding of b-catenin/TCF/LEF transcription factors, and it is Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation. What's more, MCC can interact with SCRIB(via phosphorylated PDZ-binding motif), EZR, SNX27, SLC9A3R1 and SLC9A3R2.
Western blot : 0.1-0.5μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Cell projection, Nucleus, Cytoplasm |
| Tissue Specificity: | Expressed in a variety of tissues. |
| BioGrid: | 110333. 56 interactions. |
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