Polyclonal Antibody to Anti-MCC Antibody(Discontinued)

Product code: 39-2151

Clonality : Polyclonal
Application : WB
Reactivity : Human

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Amount : 100 μg/vial
Isotype : Rabbit IgG
Purification : Immunogen affinity purified.
Content : Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage condition : At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
Gene : MCC
Gene ID : 4163
Uniprot ID : P23508
Alternative Name : Colorectal mutant cancer protein; Protein MCC; MCC
Immunogen Information : A synthetic peptide corresponding to a sequence at the C-terminus of human MCC(573-590aa IQQLKNDRAAVKLTMLEL), identical to the related mouse and rat sequences.

MUTATED IN COLORECTAL CANCERS(MCC) is a tumor suppressor gene. It is mapped to 5q22.2. This gene suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. MCC also Inhibits DNA binding of b-catenin/TCF/LEF transcription factors, and it is Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation. What's more, MCC can interact with SCRIB(via phosphorylated PDZ-binding motif), EZR, SNX27, SLC9A3R1 and SLC9A3R2.

Western blot : 0.1-0.5μg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane, Cell projection, Nucleus, Cytoplasm
Tissue Specificity: Expressed in a variety of tissues.
BioGrid: 110333. 56 interactions.
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