Polyclonal Antibody to Akt2 (Phospho-Ser474)
Figure 1: Western blot analysis of extracts from 293 cells untreated(lane 1) or treated with serum(lane 2) using Akt2(Phospho-Ser474) Antibody 35-1120 .
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
General protein kinase capable of phosphorylating several known proteins.
Sun M, et al. (2001) Cancer Res; 61(16): 5985-91.
Yuan ZQ, et al. (2000) Oncogene; 19(19): 2324-30.
Meier R, et al. (1997) J Biol Chem; 272(48): 30491-7.
Predicted MW: 60kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus, Cell membrane, Early endosome |
| Post transnational modification: | O-GlcNAcylation at Thr-306 and Thr-313 inhibits activating phosphorylation at Thr-309 via disrupting the interaction between AKT and PDK1. |
| Tissue Specificity: | Expressed in all cell types so far analyzed. |
| BioGrid: | 106711. 68 interactions. |
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