Phospho-PDK1 (Ser241) (Clone: F7) rabbit mAb

Product code: 12-4136

Clone name : PDK1S241-F7
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : Unconjugated

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Available Pack Size(s)

  •   20 µl

  •  200 µl

  • $482.00 

  • $837.00 

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For estimated delivery dates, please contact us at [email protected]


Format : Purified
Amount : 200 µl
Isotype : Rabbit IgG1k
Content : 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage condition : Store at -20°C. Avoid repeated freeze and thaw cycles.
Alternative Name : 3-phosphoinositide-dependent protein kinase 1, PDPK1
Immunogen Information : A synthetic phospho-peptide corresponding to residues surrounding Ser241 of human phospho PDK1
PDK1 is a Ser/Thr kinase that is ubiquitously expressed throughout human tissues. PDK1 phosphorylates protein kinase B (PKB or Akt) at both Thr308 and Ser473 in vivo. PDK1 is active and phosphorylated in basal conditions, where it exists predominantly in the cytosol with a small fraction at the plasma membrane. This membrane association is likely mediated by PDK1 binding to phospholipids through its PH domain, which has been found to have strong affinity to specific phospholipids. PDK1 is a master regulator of at least 23 related protein kinases, and more than 50% of all human cancers show significant overstimulation of the PDK1 pathway. Most small-molecule inhibitors of PDK1 target the ATP binding site.

1µg/mL - 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml)

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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