Mouse Monoclonal Antibody to VEGFC (Clone: 197CT7.3.4)(Discontinued)

Figure 1: All lanes : Anti-VEGFC antibody (10-6550) at 1:2000 dilution with Lane 1: CCRF-CEM whole cell lysate, Lane 2: 293 whole cell lysate, Lane 3: HepG2 whole cell lysate, Lane 4: mouse heart lysate, Lane 5: rat heart lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 47 kDa.

Mouse Monoclonal Antibody to VEGFC (Clone: 197CT7.3.4)(Discontinued)

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Figure 1: All lanes : Anti-VEGFC antibody (10-6550) at 1:2000 dilution with Lane 1: CCRF-CEM whole cell lysate, Lane 2: 293 whole cell lysate, Lane 3: HepG2 whole cell lysate, Lane 4: mouse heart lysate, Lane 5: rat heart lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 47 kDa.

Figure 2: Western blot analysis of lysates from 293, CEM cell line and mouse heart, rat heart tissue lysates (from left to right), using VEGFC Antibody (10-6550 ). VEGFC Antibody (10-6550) was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L (HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35 µg per lane.

Product code: 10-6550

Clone name :	197CT7.3.4
Clonality :	Monoclonal
Application :	WB
Reactivity :	Rat, Mouse, Human

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For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Format :	Purified
Amount :	400 µl
Isotype :	Mouse IgG1,Kappa
Purification :	Protein G Chromatography
Content :	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Storage condition :	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term store at -20°C in small aliquots to prevent freeze-thaw cycles.


Gene :	VEGFC
Gene ID :	7424
Uniprot ID :	P49767
Alternative Name :	Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Flt4-L, Vascular endothelial growth factor-related protein, VRP, VEGFC
Immunogen Information :	Recombinant Protein

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq].

WB~1:1000-2000

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted
Post transnational modification:	Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
Tissue Specificity:	Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.
BioGrid:	113267. 2 interactions.