Mouse Monoclonal Antibody to Human VISTA (Clone : VA.F6) (Discontinued)
Figure-1 : ELISA binding of VISTA antibody (Clone: VA.F6) with Human VISTA recombinant protein, Coating antigen: VISTA-Fc at 1 µg/ml, VISTA antibody dilution start from 1000 ng/ml, EC50=3.953 ng/ml.
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| Format : | Purified |
| Amount : | 40 µg |
| Isotype : | Mouse IgG2a,Kappa |
| Purification : | Protein A chromatography |
| Content : | 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide. |
| Storage condition : | The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. |
| Gene : | VSIR |
| Gene ID : | 64115 |
| Uniprot ID : | Q9H7M9 |
| Alternative Name : | VSIR/V-set immunoregulatory receptor/B7H5/ GI24/ B7-H5/ PD-1H/ SISP1/ PP2135/ C10orf54/ DD1alphaPDCD1 Homolog/V-Set Domain-Containing Immunoregulatory Receptor/V-Domain Ig Suppressor Of T Cell Activation / Chromosome 10 Open Reading Frame 54/Stress-Induced Secreted Protein-1/Stress Induced Secreted Protein 1/ Platelet Receptor GI24/ Platelet Receptor Gi24 / Death Domain1alpha |
| Immunogen Information : | Recombinant human VISTA-Fc |
VISTA is a negative immune checkpoint regulator that suppresses T-cell activation, and highly expressed on hematopoietic cells and within the tumor microenvironment. By analogy to VISTA and PD-L1 blockade, VISTA blockade may offer an immunotherapeutic strategy for human cancer. Therapeutic antibody against VISTA activates T cell signal and offers a way to promote this blockade. Human VISTA Antibody (VA.F6), mAb, Mouse is produced from a hybridoma resulting from the fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with recombinant human VISTA.
ELISA detection: 0.01-0.1 µg/ml
Flow cytometry: 5-7 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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