Mouse Monoclonal Antibody to Cyclin E(Clone: HE12)(Discontinued)
Figure 1 : Formalin fixed paraffin embedded human breast carcinoma stained with Cyclin E antibody ( 10-11523).
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| Format : | Purified |
| Amount : | 0.5 ml |
| Isotype : | Mouse IgG1 |
| Content : | This antibody is supplied as purified immunoglobulin fraction containing sodium azide as preservative. |
| Storage condition : | Store at 2-8°C. |
This antibody recognizes a doublet of 50 kDa and a single band of 42 kDa identified as cyclin E. Cyclin proteins are a family of related proteins, which control the progression of the eukaryotic cell cycle. Overexpression of cyclin E shortens the length of the G1 phase, accelerating progression of S phase. The activity of cyclin E is mediated through its activation of cyclin dependent kinase 2 (cdk2) protein and is modulated by the presence of tumor suppressor proteins such as p16.
IHC : 1:100-1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus |
| Post transnational modification: | Ubiquitinated by UHRF2; appears to occur independently of phosphorylation. |
| Tissue Specificity: | Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. |
| BioGrid: | 107338. 96 interactions. |
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