Mouse Monoclonal Antibody to CD23(Clone :BS99)(Discontinued)
Figure-1: Tonsil (Figure-1 and Figure-2) has stained with CD23 (Clone: BS99) antibody using 1:200 dilution and pH9 tris-EDTA pretreatment. B-cells of mantle zone have strong or moderate membranous label and follicular dendritic cells stained strongly.
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| Amount : | 1 ml |
| Content : | TRIS with 0.03% sodium azide, pH7.2 |
| Storage condition : | Store at 4°C |
The human leukocyte differentiation antigen CD23 (FCER2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle zone but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors.
Immunohistochemical Analysis :-1:200
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Cell membrane, Secreted |
| Post transnational modification: | The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding. |
| BioGrid: | 108502. 4 interactions. |
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