Monoclonal Antibody to TSLP Receptor (Clone: ABM28B6)
Figure 1: Western blot analysis of TSLP Receptor. Anti- TSLP Receptor antibody (Clone: ABM28B6) was tested at 2 µg/ml on (1) THP-1 and (2) human heart lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2a Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
TSLPR (thymic stromal lymphopoietin receptor) also known as CRLF2 (cytokine receptor-like factor 2) is a member of type I cytokine receptor. It binds its ligand TSLP (thymic stromal lymphopoietin) as a heterodimer with IL7R. TSLP ligand is produced by epithelial cells in order to activate dendritic cells, and is involved in inflammation, allergic responses as well as B-cell precursor proliferation and survival. The interaction between TSLP and its heterodimeric receptor activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. High expression of CRLF2 is associated with a poor prognosis in adult and high-risk pediatric cases of B-ALL (B-cell acute lymphoblastic leukemias).
Western blot analysis: 2-4 µg/ml, Flowcytometric analysis: 0.5-1 µg/10^6 Cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted |
| Tissue Specificity: | Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells. |
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