Monoclonal Antibody to TLR8/CD288 FITC Conjugated (Clone: ABM15F6)
Fig-1: Intracellular flow analysis of FITC conjugated hTLR8 in Jurkat cells using 0.5 µg/10^6 cells of FITC conjugated hTLR8 antibody (Clone: ABM15F6). Green represents isotype control; red represents anti-FITC conjugated hTLR8 antibody.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1 Kappa |
| Purification : | Protein G Chromatography |
| Content : | 0.2 mg/ml in Tris buffer containing 0.05% Azide |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. |
Toll like receptor 8, also known as CD288, is a member of TLR family. It plays an important role in sensing phagocytosed pathogen. TLR8 recognizes ssRNA and recruits MyD88 and leads to the activation of transcription factor NF-kappa B. TLR8 TLR8 has two splice variants, viz., TLR8v1 and TLR8v2 and one missense variant, termed G or A1G allele of TLR8. TLR8v1 has additional 19 amino acids in the N-terminus. It is predominantly expressed in lung and peripheral blood leukocytes.
FACS analysis: 0.5-1 µg/10^6 cells
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane |
| Tissue Specificity: | Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells. |
| BioGrid: | 119462. 1 interactions. |
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