Monoclonal Antibody to Napsin A (Clone: ABM4H60)
Fig-1: Western blot analysis of Napsin A. Anti-Napsin A antibody (Clone: ABM4H60) was tested at 2 µg/ml on (1) A549 and (2) HepG2 lysates.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1 Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
Napsin A, a human aspartic proteinase is found primarily in type II pneumocytes and alveolar macrophages and predominantly expressed in lung and kidney. It is a reliable marker for pulmonary adenocarcinoma and is expressed in a subset of ovarian clear cell carcinomas (O-CCCs), endometrial (EM) CCCs, and endometrioid carcinomas (EC). It is also useful in evaluating SH (Sclerosing hemangiomas) (23194051). Napsin A acts as an anti-apoptotic protein that promotes resistance to cisplatin by degradation of the tumor suppressor p53, which is regulator of the cell cycle and co-works with cyclin kinase inhibitors as p21 and p27.
Western blot analysis: 2-4 µg/ml; Immunohistochemical analysis: 5-10 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Ahmed ahmed
Incidence of Pulmonary Carcinogenic Changes After One Hundred Weeks of Solitary α-quartz Exposure in Albino Wistar Rats (In vivo Study)
Article 4, Volume 44, Issue 2, June 2021, Page 339-348 XMLPDF (909.88 K)
Document Type: Original Article
DOI: 10.21608/EJH.2020.30485.1291
https://ejh.journals.ekb.eg/article_96102.html
| Subcellular location: | Secreted |
| Tissue Specificity: | Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes. |
| BioGrid: | 114861. 7 interactions. |
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