Monoclonal Antibody to NALP3 (Clone: ABM2D48)
Fig-1: Western blot analysis of NALP3. Anti- NALP3 antibody (Clone: ABM2D48) was tested at 8 µg/ml on NIH 3T3 lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2b Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
NALP3 (NACHT, LRR and PYD domains-containing protein 3), otherwise known as cryopyrin, is a member of the NLR (Nod-like-receptors) family. This is a pyrin-like protein, having N-terminal CARD or pyrin domains needed for homotypic protein protein interaction, an intermediate nucleotide binding self oligomerization NACHT domain and a C-terminal domain containing leucine rich repeats (LRRs). NALP3 is a key component of innate immunity and its expression is restricted to immune cells and chondrocytes. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kB signaling, and it plays an important role in the regulation of inflammation, the immune response, and apoptosis.
Western blot analysis: 6-8 µg/ml, Immunohistochemical analysis: 5 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Inflammasome, Endoplasmic reticulum, Secreted, Nucleus |
| Post transnational modification: | The disulfide bond in the pyrin domain might play a role in reactive oxygen species-mediated activation. |
| BioGrid: | 125319. 49 interactions. |
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