Monoclonal Antibody to MUL1 (Clone: ABM4F71)
Fig-1: Western blot analysis of MUL1. Anti-MUL1 antibody (Clone: ABM4F71) was tested at 4 µg/ml on human SKM lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase-1) is a crucial moderator of RIG-I (Retinoic Acid-Inducible-Gene-I) signaling. This protein is localized to the mitochondria where it interacts with MAVS (Mitochondrial Antiviral Signaling) and catalyzes RIG-I post-translational modifications that inhibit RIG-I-dependent cell signaling. MUL1 contains a unique BAM (Beside A Membrane) domain and a C-terminal RING-finger domain. This protein has been implicated in several processes that occur in animal cells such as NF-KappaB activation, innate immunity and antiviral signaling, suppression of PINK1/parkin defects, mitophagy in skeletal muscle, and caspase-dependent apoptosis.
Western blot analysis: 4-8 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Mitochondrion outer membrane, Peroxisome |
| Post transnational modification: | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Tissue Specificity: | Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus. |
| BioGrid: | 122734. 66 interactions. |
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