Monoclonal Antibody to MLH1 (Clone: ABM4D74)
Fig-1: Immunohistochemical analysis of MLH1 in Lymphoma tissue using MLH1 antibody (Clone: ABM4D74) at 5 µg/ml.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2b |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
MutL homolog 1 (MLH1) is a member of mismatch repair genes (MMR) that plays a crucial role in correcting replication errors, cell cycle arrest, apoptosis and oxidative stress. MLH1 is a human homolog of the E.coli DNA mismatch repair gene. It mediates protein-protein interactions during mismatch recognition, strand discrimination, and strand removal. Diseases associated with MLH1 include colorectal cancer, hereditary nonpolyposis, type 2 and lynch syndrome.
Immunohistochemical analysis: 5-10 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Chromosome |
| Tissue Specificity: | Colon, lymphocytes, breast, lung, spleen, testis, prostate, thyroid, gall bladder and heart. |
| BioGrid: | 110438. 158 interactions. |
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