Monoclonal Antibody to Microtubule Associated Protein t, MAPT(Clone: 5B10)

Product code: 34-1069

Clone name : 5B10
Clonality : Monoclonal
Application : WB, ICC/IF
Reactivity : Human, Rat, Mouse

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Available Pack Size(s)

  •   50 µl

  •  100 µl

  • $402.00 

  • $462.00 

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]


Format : Purified
Amount : 100 µl
Isotype : Mouse, IgG1
Content : Antibody is supplied as an aliquot of 1 mg/ml of affinity purified antibody
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : MAPT
Gene ID : 4137
Uniprot ID : P10636
Alternative Name : Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau
Immunogen Information : Recombinant full length version of the shortest human Tau isoform purified from E. coli.

Western blot: 1:10,000. IF/ICC and IHC: 1:1,000.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Cell membrane, Cytoplasm, Cell projection, Cytoplasm, Cell projection
Post transnational modification: Glycation of PHF-tau, but not normal brain TAU/MAPT. Glycation is a non-enzymatic post-translational modification that involves a covalent linkage between a sugar and an amino group of a protein molecule forming ketoamine. Subsequent oxidation, fragmentation and/or cross-linking of ketoamine leads to the production of advanced glycation endproducts (AGES). Glycation may play a role in stabilizing PHF aggregation leading to tangle formation in AD.
Tissue Specificity: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
BioGrid: 110308. 118 interactions.
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