Monoclonal Antibody to Lamin A/C (Clone: 4C4)
Figure-1: Immunofluorescent analysis of HeLa cells stained with mouse mAb to lamin A/C,(34-1058), dilution 1:2,000 in red, and costained with rabbit pAb to HSP60, dilution 1:5,000, in green. The blue is Hoechst staining of nuclear DNA. (34-1058) antibody specifically labels the nuclear lamina, while the rabbit pAb to HSP60 antibody reveals protein expressed in mitochondria.
Roll over image to zoom in
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Mouse, IgG1 |
| Content : | Antibody is supplied as an aliquot of 1 mg/ml of affinity purified antibody. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
WB: 1:1,000-1:2,000. IF/ICC 1:1,000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus speckle |
| Post transnational modification: | Farnesylation of prelamin-A/C facilitates nuclear envelope targeting. |
| Tissue Specificity: | In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. |
| BioGrid: | 110186. 661 interactions. |
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
