Monoclonal Antibody to Ku (p70/p80) (Nuclear Marker)(Clone : KU729)
Flow Cytometry of human Ku (p70/p80) on K562 Cells. Black: Cells alone; Green: Isotype Control; Red: PE-labeled Ku Monoclonal Antibody (KU729).
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Purification : | Affinity Chromatography |
| Content : | 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
Recognizes a dimer of two proteins of 70kDa and ~80kDa, identified as two subunits of Ku. This MAb recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); ,Immunocytochemistry (Acetone-fixed cells) (0.5-1.0ug/ml for 30 minutes at RT),
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Chromosome |
| Post transnational modification: | Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair. |
| BioGrid: | 108822. 283 interactions. |
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