Monoclonal Antibody to IL-3RA (Clone: ABM25C1)
Fig-1: Western blot analysis of IL-3RA. Anti-IL-3RA antibody (Clone: ABM25C1) was used at 6 µg/ml on hbrain lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2b, Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Interleukin-3 receptor subunit alpha (IL-3RA) or CD123 is a high-affinity receptor for interleukin-3 (IL-3), which along with the primary signaling common β (βc) subunit (CD131) forms a heterodimer, enabling cell signaling. IL-3RA chain is a glycoprotein of 360 amino acidic residues, composed by an extracellular domain of 287 amino acid residues, involving a predicted Ig-like domain, two Fn III domains, a transmembrane domain of 30 amino acid residues and by an intracellular domain of 53 residues. It is expressed on the majority of CD34+ hemopoietic progenitors and its expression is rapidly lost during erythroid and megakaryocytic differentiation, moderately decreased during monocytic differentiation and is sustained in the granulocytic lineage. IL-3RA is also expressed in a variety of hematological neoplasms including blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), Hodgkin’s lymphoma and hairy cell leukemia.
WB: 6-8 µg/ml, FACS: 0.5-1 µg/10^6
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane |
| BioGrid: | 109778. 11 interactions. |
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