Monoclonal Antibody to Human PD-L1 (Clone: ABM4E54) (BSA/AZIDE Free)
Figure-1: Cell Surface FLOW analysis of PD-L1 in PHA treated human PBMC using 1 µg of PD-L1 antibody (Clone: ABM4E54). Green represents isotype control; red represents anti-PD-L1 antibody. Goat anti-mouse PE conjugate was used as secondary antibody.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2a Kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS (sterile filtered), BSA, Glycerol and Sodium azide free. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells, and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.
Western blot analysis: 2-4 µg/ml; Immunohistochemical analysis-5-10 µg/ml; FACS: 1-2 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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