Monoclonal Antibody to High mobility group box 1, Amphoterin, HMGB1(Clone: 1F3)
Figure-1: Immunofluorescent analysis of of HeLa cells stained with mouse mAb to HMGB1,(34-1051), dilution 1:2,000 in red and costained with rabbit pAb to GAPDH, (34-1048), dilution 1:2,000 in green. (34-1051) antibody stains the chromatin binding protein HMGB1, which is localized in the nuclei. In contrast the (34-1048) antibody produces strong cytoplasmic staining of cells.
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Mouse, IgG2b |
| Content : | Antibody is supplied as an aliquot of 3 mg/ml of affinity purified antibody or concentrated tissue culture supernatant. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
WB: 1:1,000-1:2,000. ICC/IF and IHC: 1:1,000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Chromosome, Cytoplasm, Secreted, Cell membrane, Endosome, Endoplasmic reticulum-Golgi intermediate compartment |
| Post transnational modification: | In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance (PubMed:24474694). Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and proinflammatory activities (By similarity). |
| Tissue Specificity: | Ubiquituous. Expressed in platelets (PubMed:11154118). |
| BioGrid: | 109389. 98 interactions. |
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