Monoclonal Antibody to Human ATF2 (Clone: ABM16E7)
Figure-1: Western blot analysis of ATF2. Anti- ATF2 antibody (Clone: ABM16E7) was tested at 2 µg/ml on PC3 lysate.
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | ATF2 |
| Gene ID : | 1386 |
| Uniprot ID : | P15336 |
| Alternative Name : | Cyclic AMP-dependent transcription factor ATF-2 , cAMP-dependent transcription factor ATF-2, Activating transcription factor 2, Cyclic AMP-responsive element-binding protein 2, HB16, Histone acetyltransferase ATF2, cAMP response element-binding protein CRE-BP1 |
| Immunogen Information : | A partial length recombinant protein of human ATF2 was used as immunogen for this antibody. |
WB: 4-6 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm, Mitochondrion outer membrane |
| Post transnational modification: | Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4. ATM-mediated phosphorylation at Ser-490 and Ser-498 stimulates its function in DNA damage response. Phosphorylation at Ser-62, Thr-73 and Ser-121 activates its transcriptional activity. Phosphorylation at Thr-69 or Thr-71 enhances its histone acetyltransferase (HAT) activity. |
| Tissue Specificity: | Ubiquitously expressed, with more abundant expression in the brain. |
| BioGrid: | 107776. 213 interactions. |
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