Monoclonal Antibody to FOXO1 (Clone: ABM4E66)

Product code: 10-4163

Clone name : ABM4E66
Clonality : Monoclonal
Application : FACS, WB
Reactivity : Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $110.00 

  • $290.00 

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Shipping Info:

Order now and get it on Wednesday November 06, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG2b Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : FOXO1
Gene ID : 2308
Uniprot ID : Q12778
Alternative Name : FOXO1, FKHR, FOXO1A
Immunogen Information : A full length recombinant FOXO1 protein was used as the immunogen for this antibody.

FOXO1 is one of the fox proteins playing pivotal roles in several human intracellular pathways. These proteins are transcription factors acting as nuclear regulator of transcriptional activity of a number of metabolic processes such as the cellular response to oxidative stress. FOXO1 protein response to oxidative stress may be linked to Alzheimer's disease (AD) by means of insulin brain resistance. FOXO1 plays a critical role in establishing and maintaining the B cell specific differentiation program, but it is also responsible for cell death due to an inappropriate BCR signaling. This protein is highly expressed in B cells, is downregulated in Hodgkin and Reed-Sternberg (HRS) cells of cHL (Classical Hodgkin Lymphoma).

Western blot analysis: 2-4 µg/ml, FACS: 0.5-1 µg/10^6 cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Post transnational modification: Once in the nucleus, acetylated by CREBBP/EP300. Acetylation diminishes the interaction with target DNA and attenuates the transcriptional activity. It increases the phosphorylation at Ser-256. Deacetylation by SIRT1 results in reactivation of the transcriptional activity. Oxidative stress by hydrogen peroxide treatment appears to promote deacetylation and uncoupling of insulin-induced phosphorylation. By contrast, resveratrol acts independently of acetylation.
Tissue Specificity: Ubiquitous.
BioGrid: 108597. 63 interactions.
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