Monoclonal Antibody to E-cadherin (Clone: ABM43F8)

Fig-1: Immunohistochemical analysis of E-cadherin in human Kidney tissue using E-cadherin antibody (Clone: ABM43F8) at 15 µg/ml.

Monoclonal Antibody to E-cadherin (Clone: ABM43F8)

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Fig-1: Immunohistochemical analysis of E-cadherin in human Kidney tissue using E-cadherin antibody (Clone: ABM43F8) at 15 µg/ml.

Fig-2 : Immunohistochemical analysis of E-cadherin in human colon adenocarcinoma tissue using E-cadherin antibody (Clone: ABM43F8) at 5 µg/ml.

Fig-3 : Immunohistochemical analysis of E-cadherin in human colon tissue using E-cadherin antibody (Clone: ABM43F8) at 15 µg/ml.

Fig-4 : Western blot analysis of E-cadherin. Anti- E-cadherin antibody (Clone: ABM43F8) was tested at 4 µg/ml on human Intestine lysate.

Product code: 10-7546

Clone name :	ABM43F8
Clonality :	Monoclonal
Application :	IHC, WB
Reactivity :	Human

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Download TDS MSDS

Format :	Purified
Amount :	100 µg
Isotype :	Mouse IgG1 Kappa
Purification :	Protein G Chromatography
Content :	25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	CDH1
Gene ID :	999
Uniprot ID :	P12830
Alternative Name :	CDH1, CDHE, UVO
Immunogen Information :	A partial length recombinant E-cadherin protein (amino acids 438-556) was used as the immunogen for this antibody .

Epithelial cadherin (E-cadherin) is a calcium dependent cell-cell adhesion glycoprotein. It is associated with gland formation, stratification, and epithelial polarization. Its deregulation affects cell-cell adhesion and results in increased invasiveness of distinct human carcinomas like gastric cancer, malignancy, oral squamous cell carcinoma, Atypical parathyroid adenoma (APA). Loss of function of E-cadherin leads to the disappearance of epithelial characteristics of the cells and generates higher invasiveness for extracellular matrices. E-cadherin expression is considered to be a decisive indicator for differentiation, aggressive behaviour, high proliferation, metastasis, poor prognosis and invasiveness of human carcinoma cells.

Western blot analysis: 4-6 µg/ml, Immunohistochemical analysis: 5-15 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cell junction, Cell membrane, Endosome, Golgi apparatus
Post transnational modification:	O-glycosylated. O-manosylated by TMTC1, TMTC2, TMTC3 or TMTC4. Thr-285 and Thr-509 are O-mannosylated by TMTC2 or TMTC4 but not TMTC1 or TMTC3.
Tissue Specificity:	Non-neural epithelial tissues.
BioGrid:	107434. 631 interactions.